Bioinformatic tool for searching, visualizing and analizing molecular interactions information around a set of genes/proteins.



Calculation and visualization of the isotopic distribution from molecular formulas or the sequence of peptides, proteins, DNA, RNA and carbohydrates.



A web application to access to information stored in SysBiomics database which integrate data on gene, proteins, protein-protein interactions, biological pathways, gene ontology, miRNA-gene silencing relations and more.

Websites of Interest







Next Events

OMICS 2015

International Meeting on Bioinformatics and Omics. Varadero Beach, Cuba. Oct 27-30.


BIG DATA in Biomedicine

Big Data in Biomedicine Conference. Standord, CA, USA. Mayo 20-22, 2015.



23rd Annual International Conference on Intelligent Systems for Molecular Biology and the 14th European Conference on Computational Biology at the Convention Center Dublin. Ireland. July 10-14.


For Internal Use


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Perera Y, Pedroso S, Borras-Hidalgo O, Vázquez DM, Miranda J, Villareal A, Falcón V, Cruz LD, Farinas HG, Perea SE. Pharmacologic inhibition of the CK2-mediated phosphorylation of B23/NPM in cancer cells selectively modulates genes related to protein synthesis, energetic metabolism, and ribosomal biogenesis. Mol Cell Biochem. 2015 Mar 25. [abstract][full text


Santos A, Machado ACecilia, Chico A, Miranda J, Rodríguez Y, Bringas R, Estévez M, Guillen GE. Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients. BMC Musculoskeletal Disorders 2015, 16:51.[abstract][full text]


Perera Y, Toro ND, Gorovaya L, Fernández-de-Cossío J, Farina HG, Perea SE. Synergistic interactions of the anti-casein kinase 2 CIGB-300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models. Mol Clin Oncol. 2014 Nov, 2(6):935-944. [abstract][full text]


Masforrol Y, Gil J, González LJ, Pérez-Riverol Y, Fernández-de-Cossío J, Sánchez A, Betancourt LH, Garay HE, Cabrales A, Albericio F, Yang H, Zubarev RA, Besada V, Acosta OR. Introducing an Asp-Pro linker in the synthesis of random one-bead-one-compound hexapeptide libraries compatible with ESI-MS analysis. ACS Comb Sci. 2012 Mar 12;14(3):145-9. [abstract] [full text]



Junco JA, Fuentes F, Basulto R, Bover E, Castro MD, Pimentel E, Reyes O, Bringas R, Calzada L, López Y, Arteaga N, Rodríguez A, Garay H, Rodríguez R, González-Quiza L, Fong , Guillén GE. Prostate Cancer Immunotherapy – Strategy with a Synthetic GnRH Based Vaccine Candidate. Edited by Hilal Arnouk, ISBN 978-953-307-998-1. [abstract] [full text]



Berlanga-Acosta J, Vázquez-Blomquist D, Cibrián D, Mendoza Y, Ochagavía ME, Miranda J, Suárez J, González-Ferrer Y, Vila JM, Abreu A, Ugarte-Moreno D, Cruz Y, Howland I, Coro-Antich R, León OS, Bringas R, García-del Barco D, Cosme-Díaz K, Palenzuela D, Fernández JR, Nazabal M, Guillén I, Cintado A, Novoa LI, López-Mola E, Guillén-Nieto GE. Growth Hormone Releasing Peptide 6 (GHRP6) reduces liver fibrosis in CCl4 chronically intoxicated rats. Biotecnol Apl [online]. 2012, vol.29, n.2 [citado 2012-11-22], pp. 60-72. [abstract] [full text]



Guillén IA, Camacho H, Fernández ME, Palenzuela DO, Pérez L, Ochagavía ME, Ancizar JA, Tuero AD, Gorovaya L, Mendoza O, Díaz T, Fernández JR, Roca J, Cosme K, Guillén-Nieto GE, Herrera L, Berlanga J, Novoa LI. Effect of human epidermal growth factor on the tumor cell line A431: in vivo analysis of tumor growth inhibition and gene expression. Biotecnol Apl [online]. 2012, vol.29, n.3 [citado 2012-11-22], pp. 155-161. [abstract] [full text]



Vázquez-Blomquist D, Fernández JR, Miranda J, Bello C, Silva JA, Estrada RC, Novoa LI, Palenzuela D, Bello I. Selection of reference genes for use in quantitative reverse transcription PCR assays when using interferons in U87MG. Mol Biol Rep. 2012 Dec;39(12):11167-75. [abstract] [full text]



Fernandez-de-Cossio Diaz J, Fernandez-de-Cossío J. Computation of isotopic peak center-mass distribution by Fourier transform. Anal Chem. 2012 Aug 21;84(16):7052-6. [abstract] [full text]



Fernandez-de-Cossio J. Mass spectrum patterns of 18O-tagged peptides labeled by enzyme-catalyzed oxygen exchange. Anal Chem. 2011 Apr 15;83(8):2890-6.doi: 10.1021/ac1025368. Epub 2011 Mar 18. PMID: 21417365 [PubMed - indexed for MEDLINE] [abstract] [full text]



Betancourt LH, Sánchez A, Pérez Y, Fernandez de Cossio J, Gil J, Toledo P, Iguchi S, Aimoto S, González LJ, Padrón G, Takao T, Besada V. Charge state-selective separation of peptides by reversible modification of amino groups and strong cation-exchange chromatography: evaluation in proteomic studies using peptide-centric database searches. J Proteomics. 2011 Sep 6;74(10):2210-3. doi: 10.1016/j.jprot.2011.04.029. Epub 2011 May 9. PMID: 21596166 [PubMed - indexed for MEDLINE] [abstract] [full text]



Ochagavía ME, Miranda J, Nazábal M, Martin A, Novoa LI, Bringas R, Fernández-De- Cossío J, Camacho H. A methodology based on molecular interactions and pathways to find candidate genes associated to diseases: its application to schizophrenia and alzheimer's disease. Journal of Bioinformatics and Computational Biology 2011 9(4). DOI No: 10.1142/S0219720011005392. [abstract] [full text]



Sanchez A, Sun W, Wang L, Ma J, Betancourt L, Gil J, Perez-Riverol Y, Fernandez de-Cossio J, Padron G, Jiang Y, He F, Gonzalez LJ, Besada V. Selective isolation-detection of two different positively charged peptides groups by strong cation exchange chromatography and matrix-assisted laser desorption/ionization mass spectrometry: application to proteomics studies. Eur J Mass Spectrom (Chichester, Eng). 2010;16(6):693-702.[abstract] [full text].



Rodríguez-Ulloa A, Ramos Y, Gil J, Perera Y, Castellanos-Serra L, García Y, Betancourt L, Besada V, González LJ, Fernández-de-Cossio J, Sanchez A, Serrano JM, Farina H, Alonso DF, Acevedo BE, Padrón G, Musacchio A, Perea SE. Proteomic profile regulated by the anticancer peptide CIGB-300 in non-small cell lung cancer (NSCLC) cells. J Proteome Res. 2010 Oct 1;9(10):5473-83. [abstract][full text]



Fernandez-de-Cossio J. Computation of the Isotopic Distribution in Two Dimensions. Anal Chem. 2010 Aug 1;82(15):6726-9. 2010 Jul 8. [abstract][full text]



Martin A, Ochagavia ME, Rabasa LC, Miranda J, Fernandez-de-Cossio J, Bringas R. Bisogenet: A new tool for gene network building, visualization and analysis. BMC Bioinformatics , 10:91 , 2010. [abstract][full text]



Fernandez-de-Cossio J. Efficient Packing Fourier-Transform Approach for Ultrahigh Resolution Isotopic Distribution Calculations. Anal Chem. 2010 Mar 1;82(5):1759-65.[abstract] [full text]



Trujillo LE, Menéndez C, Ochagavía ME, Hernández I, Borrás O, Rodríguez R, Coll Y, Arrieta JG, Banguela A, Ramírez R, Hernández L. Engineering drought and salt tolerance in plants using SodERF3, a novel sugarcane ethylene responsive factor. Biotecnología Aplicada 26(2):168-171, 2009.[abstract] [full text]



Cutiño-Jiménez AM, Martins-Pinheiro M, Lima WC, Martín-Tornet A, Morales OG, Menck CFM. Evolutionary placement of xanthomonadales based on conserved protein signature sequences. Molecular Phylogenetics and Evolution, 2009.[abstract] [full text]



Sánchez A, Betancourt L, González LJ, Ramos Y, Gil J, Solano Y, Morera V, García Y, Álvarez F, Moya G, Fernández-de-Cossio J, Padrón G, Besada V. Desarrollo de nuevos métodos para el estudio del péptido N-terminal de proteínas y sus aplicaciones en la industria biotecnológica. Biotecnología Aplicada 25(4):384-387, 2008.[abstract] [full text]



Junco J.A., Basulto R., Fuentes F., Bover E., Reyes O., Pimentel E., Calzada L., Castro M.D.,Arteaga N., López Y., Hernández H., Bringas R., Garay H., Peschke P., Bertot J., Guillén G. Gonadotropin Releasing Hormone-Based Vaccine, an Effective Candidate for Prostate Cancer and Other Hormone-sensitive Neoplasms. In: Adv Exp Med Biol 617:581-7, 2008. [abstract] [full text]



Junco JA, Basulto R, Fuentes F, Bover E, Castro MD, Reyes O, Pimentel E, Calzada L, López Y, Bringas R, Arteaga N, Hernández H, Garay H, Aguero L, Guillén G. Inducción de ablación androgénica e inhibición de tumores hormonosensibles de próstata mediante la inmunización con el péptido sintético GnRHm1-TT adyuvado con VSSP. Biotecnología Aplicada 25(2):171-173, 2008. [abstract] [full text]



Miranda J, Bringas R. Análisis de Datos de Microarreglos de ADN. Part I: Antecedentes de la tecnología y diseño experimental. Biotecnología Aplicada 25. 2008 [abstract] [full text]


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